全文获取类型
收费全文 | 258372篇 |
免费 | 21072篇 |
国内免费 | 9138篇 |
专业分类
耳鼻咽喉 | 1491篇 |
儿科学 | 8830篇 |
妇产科学 | 1986篇 |
基础医学 | 29332篇 |
口腔科学 | 3941篇 |
临床医学 | 26113篇 |
内科学 | 65992篇 |
皮肤病学 | 3249篇 |
神经病学 | 26786篇 |
特种医学 | 6804篇 |
外国民族医学 | 11篇 |
外科学 | 18285篇 |
综合类 | 35842篇 |
现状与发展 | 48篇 |
一般理论 | 9篇 |
预防医学 | 23478篇 |
眼科学 | 2693篇 |
药学 | 17261篇 |
194篇 | |
中国医学 | 10687篇 |
肿瘤学 | 5550篇 |
出版年
2024年 | 236篇 |
2023年 | 4804篇 |
2022年 | 6479篇 |
2021年 | 12467篇 |
2020年 | 12301篇 |
2019年 | 9606篇 |
2018年 | 9544篇 |
2017年 | 9481篇 |
2016年 | 10049篇 |
2015年 | 10056篇 |
2014年 | 18190篇 |
2013年 | 19811篇 |
2012年 | 15364篇 |
2011年 | 16826篇 |
2010年 | 13399篇 |
2009年 | 12704篇 |
2008年 | 12696篇 |
2007年 | 12523篇 |
2006年 | 11162篇 |
2005年 | 9322篇 |
2004年 | 7982篇 |
2003年 | 6869篇 |
2002年 | 5725篇 |
2001年 | 5068篇 |
2000年 | 4175篇 |
1999年 | 3516篇 |
1998年 | 3094篇 |
1997年 | 2737篇 |
1996年 | 2366篇 |
1995年 | 2533篇 |
1994年 | 2335篇 |
1993年 | 1959篇 |
1992年 | 1781篇 |
1991年 | 1565篇 |
1990年 | 1271篇 |
1989年 | 1091篇 |
1988年 | 1020篇 |
1987年 | 895篇 |
1986年 | 769篇 |
1985年 | 1007篇 |
1984年 | 785篇 |
1983年 | 505篇 |
1982年 | 560篇 |
1981年 | 468篇 |
1980年 | 345篇 |
1979年 | 304篇 |
1978年 | 234篇 |
1977年 | 192篇 |
1976年 | 163篇 |
1975年 | 55篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
目的研究慢阻肺急性加重期患者延迟就医与家庭动力学的相关性,希望能够为慢阻肺急性加重期患者拟定护理措施提供科学依据。方法选取2017年1月-2019年12月我院240例诊断为慢阻肺急性加重期的患者为研究对象。根据患者入院就医的时间进行分组,时间≥24h的延迟就医的患者为观察组,时间<24h的及时就医患者为对照组。结果两组患者在文化水平、家庭年收入、在职状态、医疗保险和婚姻状况和APACHEⅡ评分比较(P<0.05)。观察组患者疾病观念、个性化、系统逻辑和家庭氛围得分比对照组高(P<0.05)。Pearman的相关性分析结果显示:慢阻肺急性加重期患者延迟就医时间与各个层面分数以及家庭动力总分呈现负相关性(P<0.05)。应变量为延迟就医为应变量,患者的一般资料为自变量,经Logistic回归分析结果表明:延迟就医的影响因素为文化水平、家庭动力评分、职业状态、家庭收入、婚姻状况和APACHEⅡ评分。结论慢阻肺急性加重期患者家庭动力总分与疾病观念、个性化、系统逻辑和家庭氛围得分与延迟就医时间呈现负相关性,患者延迟就医的影响因素是家庭动力学评分。 相似文献
22.
《Vaccine》2022,40(7):1001-1009
Vaccination guidelines for dogs and cats indicate that core vaccines (for dogs, rabies, distemper, adenovirus, parvovirus; for cats, feline parvovirus, herpes virus-1, calicivirus) are essential to maintain health, and that non-core vaccines be administered according to a clinician’s assessment of a pet’s risk of exposure and susceptibility to infection. A reliance on individual risk assessment introduces the potential for between-practice inconsistencies in non-core vaccine recommendations. A study was initiated to determine non-core vaccination rates of dogs (Leptospira, Borrelia burgdorferi, Bordetella bronchiseptica, canine influenza virus) and cats (feline leukemia virus) in patients current for core vaccines in veterinary practices across the United States. Transactional data for 5,531,866 dogs (1,670 practices) and 1,914,373 cats (1,661 practices) were retrieved from practice management systems for the period November 1, 2016 through January 1, 2020, deidentified and normalized. Non-core vaccination status was evaluated in 2,798,875 dogs and 788,772 cats that were core-vaccine current. Nationally, median clinic vaccination rates for dogs were highest for leptospirosis (70.5%) and B. bronchiseptica (68.7%), and much lower for canine influenza (4.8%). In Lyme-endemic states, the median clinic borreliosis vaccination rate was 51.8%. Feline leukemia median clinic vaccination rates were low for adult cats (34.6%) and for kittens and 1-year old cats (36.8%). Individual clinic vaccination rates ranged from 0 to 100% for leptospirosis, B. bronchiseptica and feline leukemia, 0–96% for canine influenza, and 0–94% for borreliosis. Wide variation in non-core vaccination rates between clinics in similar geographies indicates that factors other than disease risk are driving the use of non-core vaccines in pet dogs and cats, highlighting a need for veterinary practices to address gaps in patient protection. Failure to implement effective non-core vaccination strategies leaves susceptible dogs and cats unprotected against vaccine-preventable diseases. 相似文献
23.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease. Fluoxetine has been shown to increase hepatic lipid accumulation in vivo and in vitro. In addition, fluoxetine has been shown to alter the production of prostaglandins which have also been implicated in the development of non-alcoholic fatty liver disease. The goal of this study was to assess the effect of fluoxetine exposure on the prostaglandin biosynthetic pathway and lipid accumulation in a hepatic cell line (H4-II-E-C3 cells). Fluoxetine treatment increased mRNA expression of prostaglandin biosynthetic enzymes (Ptgs1, Ptgs2, and Ptgds), PPAR gamma (Pparg), and PPAR gamma downstream targets involved in fatty acid uptake (Cd36, Fatp2, and Fatp5) as well as production of 15-deoxy-Δ12,14PGJ2 a PPAR gamma ligand. The effects of fluoxetine to induce lipid accumulation were attenuated with a PTGS1 specific inhibitor (SC-560), whereas inhibition of PTGS2 had no effect. Moreover, SC-560 attenuated 15-deoxy-Δ12,14PGJ2 production and expression of PPAR gamma downstream target genes. Taken together these results suggest that fluoxetine-induced lipid abnormalities appear to be mediated via PTGS1 and its downstream product 15d-PGJ2 and suggest a novel therapeutic target to prevent some of the adverse effects of fluoxetine treatment. 相似文献
24.
25.
26.
27.
28.
《Transfusion and apheresis science》2022,61(3):103347
Gestational alloimmune liver disease (GALD) is a materno-fetal alloimmune disorder that targets the fetal liver and often causes neonatal liver failure. GALD most commonly presents as neonatal hemochromatosis (NH), which is a severe neonatal liver injury confirmed by extra-hepatic iron accumulation at various sites. With the discovery of the alloimmune mechanism of GALD, exchange transfusion and intravenous immunoglobulin (IVIG) administration are being used as novel treatments. Here, we present a rare case of an 11-day-old female infant who presented with marked hyperbilirubinemia. Laboratory findings showed significantly elevated direct and indirect bilirubin, high ferritin and alpha fetoprotein levels, high transferrin saturation, and severe coagulopathy. Abdominal magnetic resonance imaging revealed markedly reduced T2 signal intensity in the liver and pancreas compared to the spleen, suggesting iron deposition. The infant was diagnosed with NH and successfully treated with exchange transfusion and four doses of IVIG. 相似文献
29.
30.